InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Polr2l

Summary

InnateDB Protein

IDBP-212293.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Polr2l

Protein Name

polymerase (RNA) II (DNA directed) polypeptide L

Synonyms

2510029B14Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043204

InnateDB Gene

IDBG-212291 (Polr2l)

Protein Structure

UniProt Annotation

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001054	RNA polymerase I activity
GO:0001055	RNA polymerase II activity
GO:0001056	RNA polymerase III activity
GO:0003677	DNA binding
GO:0003899	DNA-directed RNA polymerase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006360	transcription from RNA polymerase I promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006383	transcription from RNA polymerase III promoter

Cellular Component

GO:0005634	nucleus
GO:0005665	DNA-directed RNA polymerase II, core complex
GO:0005666	DNA-directed RNA polymerase III complex
GO:0005736	DNA-directed RNA polymerase I complex