InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ube2c

Summary

InnateDB Protein

IDBP-212318.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ube2c

Protein Name

ubiquitin-conjugating enzyme E2C

Synonyms

1110015A16Rik; D2Ertd695e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000085581

InnateDB Gene

IDBG-212316 (Ube2c)

Protein Structure

UniProt Annotation

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	60 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0008054	cyclin catabolic process
GO:0010458	exit from mitosis
GO:0010994	free ubiquitin chain polymerization
GO:0016567	protein ubiquitination
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031536	positive regulation of exit from mitosis
GO:0070936	protein K48-linked ubiquitination
GO:0070979	protein K11-linked ubiquitination