InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acot8

Summary

InnateDB Protein

IDBP-212353.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acot8

Protein Name

acyl-CoA thioesterase 8

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099383

InnateDB Gene

IDBG-212349 (Acot8)

Protein Structure

UniProt Annotation

Function

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium- length fatty acyl-CoAs. May be involved in the metabolic regulation of peroxisome proliferation.

Subcellular Localization

Peroxisome.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0016290	palmitoyl-CoA hydrolase activity
GO:0033882	choloyl-CoA hydrolase activity
GO:0047617	acyl-CoA hydrolase activity
GO:0052815	medium-chain acyl-CoA hydrolase activity