InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dhx8

Summary

InnateDB Protein

IDBP-212356.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dhx8

Protein Name

DEAH (Asp-Glu-Ala-His) box polypeptide 8

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037251

InnateDB Gene

IDBG-212354 (Dhx8)

Protein Structure

UniProt Annotation

Function

Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006397	mRNA processing
GO:0008380	RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

MGI:1306823

InterPro

IPR001650 Helicase, C-terminal
IPR003029 Ribosomal protein S1, RNA-binding domain
IPR007502 Helicase-associated domain
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR011709 Domain of unknown function DUF1605
IPR012340 Nucleic acid-binding, OB-fold
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR022967 RNA-binding domain, S1
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00575
PF04408
PF00270
PF07717

PRINTS

PIRSF

SMART

SM00490
SM00847
SM00487
SM00316

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A2A4P0