InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Muc2

Summary

InnateDB Protein

IDBP-212359.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Muc2

Protein Name

mucin 2

Synonyms

2010015E03Rik; MCM; wnn;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026590

InnateDB Gene

IDBG-212357 (Muc2)

Protein Structure

UniProt Annotation

Function

Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. {ECO:0000250UniProtKB:Q02817, ECO:0000269PubMed:18806221, ECO:0000269PubMed:19432394}.

Subcellular Localization

Secreted {ECO:0000269PubMed:18806221, ECO:0000269PubMed:19432394}. Note=In the intestine, secreted into the inner and outer mucus layers.

Disease Associations

Tissue Specificity

Highly expressed in goblet cells of the colon with lower levels in the small intestine and no expression in the stomach (at protein level). {ECO:0000269PubMed:14984930, ECO:0000269PubMed:9886986}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030414	peptidase inhibitor activity

Biological Process

GO:0002064	epithelial cell development
GO:0006915	apoptotic process
GO:0008285	negative regulation of cell proliferation
GO:0030336	negative regulation of cell migration
GO:0043065	positive regulation of apoptotic process

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0070702	inner mucus layer
GO:0070703	outer mucus layer

Protein Structure and Domains

PDB ID

MGI:1339364

InterPro

IPR001007 von Willebrand factor, type C
IPR002919 Trypsin Inhibitor-like, cysteine rich domain
IPR006207 Cystine knot, C-terminal
IPR006208 Glycoprotein hormone subunit beta, cystine knot
IPR008037 Proteinase inhibitor I19, pacifastin
IPR014853 Uncharacterised domain, cysteine-rich
IPR029034 Cystine-knot cytokine

PFAM

PF00093
PF01826
PF00007
PF05375
PF08742

PRINTS

PIRSF

SMART

SM00214
SM00041
SM00832

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80Z19