Version 5.4
Mus musculus Protein: Pcif1
Summary
InnateDB Protein IDBP-212431.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pcif1
Protein Name PDX1 C-terminal inhibiting factor 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000039555
InnateDB Gene IDBG-212429 (Pcif1)
Protein Structure
UniProt Annotation
Function May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0010923 negative regulation of phosphatase activity
Cellular Component
GO:0005634 nucleus
GO:0015629 actin cytoskeleton
GO:0015630 microtubule cytoskeleton
GO:0045171 intercellular bridge
Protein Structure and Domains
PDB ID MGI:2443858
InterPro IPR001202 WW domain
IPR022035 Phosphorylated CTD interacting factor 1, WW domain
IPR029048 Heat shock protein 70kD, C-terminal domain
PFAM PF00397
PF12237
PRINTS
PIRSF
SMART SM00456
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P59114
PhosphoSite PhosphoSite-P59114
TrEMBL Q542C3
UniProt Splice Variant
Entrez Gene 228866
UniGene Mm.241134
RefSeq NP_666241
MGI ID
MGI Symbol Pcif1
OMIM
CCDS CCDS17064
HPRD
IMGT
EMBL AK089358 AK150740 BC031431 CH466551
GenPept AAH31431 BAC40853 BAE29814 EDL06432

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca