Version 5.4
Mus musculus Protein: Ncoa5
Summary
InnateDB Protein IDBP-212530.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ncoa5
Protein Name nuclear receptor coactivator 5
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000046388
InnateDB Gene IDBG-212528 (Ncoa5)
Protein Structure
UniProt Annotation
Function Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2) (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008150 biological_process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0015629 actin cytoskeleton
Protein Structure and Domains
PDB ID MGI:2385165
InterPro IPR004154 Anticodon-binding
PFAM PF03129
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91W39
PhosphoSite PhosphoSite-Q91W39
TrEMBL Q8BX12
UniProt Splice Variant
Entrez Gene 228869
UniGene Mm.470785
RefSeq NP_659141
MGI ID
MGI Symbol Ncoa5
OMIM
CCDS CCDS17068
HPRD
IMGT
EMBL AK049242 AL591495 BC017152
GenPept AAH17152 BAC33631 CAM26468

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca