Version 5.4
Mus musculus Protein: Elmo2
Summary
InnateDB Protein IDBP-212613.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Elmo2
Protein Name engulfment and cell motility 2, ced-12 homolog (C. elegans)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000099377
InnateDB Gene IDBG-212599 (Elmo2)
Protein Structure
UniProt Annotation
Function Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Membrane {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0017124 SH3 domain binding
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0006909 phagocytosis
GO:0006915 apoptotic process
GO:0060326 cell chemotaxis
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:2153045
InterPro IPR006816 Engulfment/cell motility, ELMO
IPR016024 Armadillo-type fold
IPR024574 Domain of unknown function DUF3361
PFAM PF04727
PF11841
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BHL5
PhosphoSite PhosphoSite-Q8BHL5
TrEMBL Q5GMG0
UniProt Splice Variant
Entrez Gene 140579
UniGene Mm.410913
RefSeq XP_006498803
MGI ID
MGI Symbol Elmo2
OMIM
CCDS CCDS17077
HPRD
IMGT
EMBL AB093301 AF398884 AK004448 AK032033 AK033918 AK035710 AK038455 AK045428 AK047040 AK050823 AK053574 AL591430 BC023954
GenPept AAH23954 AAL14465 BAB23307 BAC27662 BAC28514 BAC29162 BAC30007 BAC32361 BAC32945 BAC34424 BAC35433 BAC41483 CAI51618 CAM23849

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca