InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itga2b

Summary

InnateDB Protein

IDBP-212669.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itga2b

Protein Name

integrin alpha 2b

Synonyms

AI172977; alphaIIb; CD41; CD41B; GpIIb;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099375

InnateDB Gene

IDBG-212667 (Itga2b)

Protein Structure

UniProt Annotation

Function

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0050840	extracellular matrix binding
GO:0070051	fibrinogen binding

Biological Process

GO:0002687	positive regulation of leukocyte migration
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0070527	platelet aggregation

Cellular Component

GO:0005925	focal adhesion
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

MGI:96601

InterPro

IPR000413 Integrin alpha chain
IPR013517 FG-GAP repeat
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site

PFAM

PF01839
PF14312
PF08441
PF00357

PRINTS

PR01185

PIRSF

SMART

SM00191

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt