InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd81

Summary

InnateDB Protein

IDBP-212679.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd81

Protein Name

CD81 antigen

Synonyms

Tapa-1; Tapa1; Tspan28;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043768

InnateDB Gene

IDBG-212677 (Cd81)

Protein Structure

UniProt Annotation

Function

May play an important role in the regulation of lymphoma cell growth. May be involved in the acrosome reaction. {ECO:0000269PubMed:17290409}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in oocytes. Highly expressed in granulosa cells. {ECO:0000269PubMed:16380109, ECO:0000269PubMed:17290409}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0023026	MHC class II protein complex binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0006661	phosphatidylinositol biosynthetic process
GO:0008104	protein localization
GO:0008284	positive regulation of cell proliferation
GO:0030307	positive regulation of cell growth
GO:0030890	positive regulation of B cell proliferation
GO:0043128	positive regulation of 1-phosphatidylinositol 4-kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0046488	phosphatidylinositol metabolic process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation

Cellular Component

GO:0001772	immunological synapse
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031982	vesicle
GO:0070062	extracellular vesicular exosome