InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ocstamp

Summary

InnateDB Protein

IDBP-212709.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ocstamp

Protein Name

RIKEN cDNA 4833422F24 gene

Synonyms

4833422F24Rik; OC-STAMP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029213

InnateDB Gene

IDBG-212707 (Ocstamp)

Protein Structure

UniProt Annotation

Function

Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation. {ECO:0000269PubMed:18064667, ECO:0000269PubMed:20882308, ECO:0000269PubMed:22337159}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in osteoclast (at protein level). Ubiquitous. Highly expressed in multi-nuclear osteoclast cells compared to mono-nuclear macrophages. Expressed in foreign body giant cells (FBGCs). {ECO:0000269PubMed:18064667, ECO:0000269PubMed:20882308, ECO:0000269PubMed:22337159}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0034241	positive regulation of macrophage fusion
GO:0045672	positive regulation of osteoclast differentiation
GO:0071356	cellular response to tumor necrosis factor
GO:0071391	cellular response to estrogen stimulus
GO:0072674	multinuclear osteoclast differentiation
GO:0090290	positive regulation of osteoclast proliferation