InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fzd2

Summary

InnateDB Protein

IDBP-212724.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fzd2

Protein Name

frizzled homolog 2 (Drosophila)

Synonyms

AL033370; AW456835; Fz10; Fzd10; Mfz10; Mfz10a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000091463

InnateDB Gene

IDBG-212722 (Fzd2)

Protein Structure

UniProt Annotation

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Subcellular Localization

Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in embryonic and adult heart, lung, chondrocytes and brain. Also expressed in the developing gastrointestinal tract (strongest in foregut), much weaker expression in the adult. No expression in fetal liver and adult spleen. Up-regulated in esophageal squamous cell carcinomas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001944	vasculature development
GO:0003149	membranous septum morphogenesis
GO:0003150	muscular septum morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007166	cell surface receptor signaling pathway
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway
GO:0007267	cell-cell signaling
GO:0007409	axonogenesis
GO:0007420	brain development
GO:0007608	sensory perception of smell
GO:0008406	gonad development
GO:0030825	positive regulation of cGMP metabolic process
GO:0030855	epithelial cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060022	hard palate development
GO:0060070	canonical Wnt signaling pathway
GO:0060119	inner ear receptor cell development
GO:0060412	ventricular septum morphogenesis
GO:0090103	cochlea morphogenesis
GO:0090179	planar cell polarity pathway involved in neural tube closure

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032589	neuron projection membrane
GO:0045177	apical part of cell