InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnfrsf22

Summary

InnateDB Protein

IDBP-212787.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfrsf22

Protein Name

tumor necrosis factor receptor superfamily, member 22

Synonyms

2810028K06Rik; C130035G06Rik; mDcTrailr2; SOBa; Tnfrh2; Tnfrsf1al2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075018

InnateDB Gene

IDBG-212785 (Tnfrsf22)

Protein Structure

UniProt Annotation

Function

Receptor for the cytotoxic ligand TNFSF10/TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. Protects cells against TRAIL mediated apoptosis possibly through ligand competition. Cannot induce the NF-kappa-B pathway. {ECO:0000269PubMed:12466268}.

Subcellular Localization

Isoform 1: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.Isoform 2: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0045569	TRAIL binding

Biological Process

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0005576	extracellular region
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1930270

InterPro

IPR001368 TNFR/NGFR cysteine-rich region

PFAM

PF00020

PRINTS

PIRSF

SMART

SM00208

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ER62

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

79202

UniGene

Mm.261384

RefSeq

XP_006508725

MGI ID

MGI Symbol

Tnfrsf22

OMIM

CCDS

HPRD

IMGT

EMBL

AJ276505 AJ278265 AK012838 AY046551 AY165626 AY165627

GenPept

AAL05073 AAN87806 AAN87807 BAB28502 CAC16406 CAC27353