InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnfrsf22

Summary

InnateDB Protein

IDBP-212789.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfrsf22

Protein Name

tumor necrosis factor receptor superfamily, member 22

Synonyms

2810028K06Rik; C130035G06Rik; mDcTrailr2; SOBa; Tnfrh2; Tnfrsf1al2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081432

InnateDB Gene

IDBG-212785 (Tnfrsf22)

Protein Structure

UniProt Annotation

Function

Receptor for the cytotoxic ligand TNFSF10/TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. Protects cells against TRAIL mediated apoptosis possibly through ligand competition. Cannot induce the NF-kappa-B pathway. {ECO:0000269PubMed:12466268}.

Subcellular Localization

Isoform 1: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.Isoform 2: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0045569	TRAIL binding

Biological Process

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0005576	extracellular region
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1930270

InterPro

IPR001368 TNFR/NGFR cysteine-rich region

PFAM

PF00020

PRINTS

PIRSF

SMART

SM00208

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ER62

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

79202

UniGene

Mm.261384

RefSeq

MGI ID

MGI Symbol

Tnfrsf22

OMIM

CCDS

CCDS22043

HPRD

IMGT

EMBL

AJ276505 AJ278265 AK012838 AY046551 AY165626 AY165627

GenPept

AAL05073 AAN87806 AAN87807 BAB28502 CAC16406 CAC27353