InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ncoa3

Summary

InnateDB Protein

IDBP-212834.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Ncoa3

Protein Name

nuclear receptor coactivator 3

Synonyms

2010305B15Rik; Actr; Aib1; AW321064; bHLHe42; KAT13B; p/Cip; pCip; Rac3; Src3; Tram-1; Tram1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000085416

InnateDB Gene

IDBG-212832 (Ncoa3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 112 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	45 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	112 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0035257	nuclear hormone receptor binding
GO:0046983	protein dimerization activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0010628	positive regulation of gene expression
GO:0016573	histone acetylation
GO:0035264	multicellular organism growth
GO:0045618	positive regulation of keratinocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048589	developmental growth
GO:0060068	vagina development
GO:0060713	labyrinthine layer morphogenesis
GO:0060744	mammary gland branching involved in thelarche
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1276535

InterPro

IPR000014 PAS domain
IPR009110 Nuclear receptor coactivator, interlocking
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR013767 PAS fold
IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking
IPR014935 Steroid receptor coactivator
IPR017426 Nuclear receptor coactivator

PFAM

PF13188
PF13426
PF00010
PF00989
PF08815
PF08832

PRINTS

PIRSF

PIRSF038181

SMART

SM00091
SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt