InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kif18b

Summary

InnateDB Protein

IDBP-212856.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kif18b

Protein Name

kinesin family member 18B

Synonyms

3000004C01Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021311

InnateDB Gene

IDBG-212854 (Kif18b)

Protein Structure

UniProt Annotation

Function

In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000305}. Note=Present predominantly in the nucleus and to a lesser extent in the cytoplasm of interphase cells. During mitosis, found to be closely associated with astral microtubule plus ends emanating from the spindle pole during prometaphase and metaphase (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0019894	kinesin binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007018	microtubule-based movement
GO:0007019	microtubule depolymerization
GO:0007067	mitotic nuclear division
GO:0008152	metabolic process
GO:0051302	regulation of cell division

Cellular Component

GO:0000235	astral microtubule
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0035371	microtubule plus-end