InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Shank2

Summary

InnateDB Protein

IDBP-212866.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Shank2

Protein Name

SH3/ankyrin domain gene 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095542

InnateDB Gene

IDBG-212862 (Shank2)

Protein Structure

UniProt Annotation

Function

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction (By similarity). {ECO:0000250}.

Subcellular Localization

Apical cell membrane {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:15207857}. Cell junction, synapse {ECO:0000269PubMed:15207857}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000269PubMed:15207857}. Cell projection, dendritic spine {ECO:0000269PubMed:15207857}. Cell projection, growth cone {ECO:0000250}. Note=Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells (By similarity). Present in the dendritic spines of cerebellar Purkinje cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in brain (at protein level), where it is highly expressed in Purkinje cells. {ECO:0000269PubMed:17244609, ECO:0000269PubMed:21423165, ECO:0000269PubMed:9742101}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0035255	ionotropic glutamate receptor binding

Biological Process

GO:0007416	synapse assembly
GO:0007612	learning
GO:0007613	memory
GO:0030534	adult behavior
GO:0035176	social behavior
GO:0035640	exploration behavior
GO:0060291	long-term synaptic potentiation
GO:0060292	long term synaptic depression
GO:0071625	vocalization behavior

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005883	neurofilament
GO:0005886	plasma membrane
GO:0008328	ionotropic glutamate receptor complex
GO:0014069	postsynaptic density
GO:0016324	apical plasma membrane
GO:0030054	cell junction
GO:0030426	growth cone
GO:0031526	brush border membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043197	dendritic spine
GO:0045211	postsynaptic membrane
GO:0060170	ciliary membrane

Protein Structure and Domains

PDB ID

MGI:2671987

InterPro

IPR001478 PDZ domain
IPR001660 Sterile alpha motif domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF00595
PF13180
PF07647
PF00536

PRINTS

PIRSF

SMART

SM00228
SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80Z38