InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cse1l

Summary

InnateDB Protein

IDBP-212950.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cse1l

Protein Name

chromosome segregation 1-like (S. cerevisiae)

Synonyms

2610100P18Rik; AA407533; Capts; Cas; Xpo2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002790

InnateDB Gene

IDBG-212948 (Cse1l)

Protein Structure

UniProt Annotation

Function

Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Subcellular Localization

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.