InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fgf15

Summary

InnateDB Protein

IDBP-212956.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fgf15

Protein Name

fibroblast growth factor 15

Synonyms

FGF19;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033389

InnateDB Gene

IDBG-212954 (Fgf15)

Protein Structure

UniProt Annotation

Function

Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression. {ECO:0000269PubMed:16213224}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in the developing brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005104	fibroblast growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001755	neural crest cell migration
GO:0007507	heart development
GO:0008284	positive regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0046326	positive regulation of glucose import
GO:0046330	positive regulation of JNK cascade
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070858	negative regulation of bile acid biosynthetic process