InnateDB Protein
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IDBP-212969.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Hexim1
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Protein Name
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hexamethylene bis-acetamide inducible 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000057339
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InnateDB Gene
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IDBG-212967 (Hexim1)
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Protein Structure
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Function |
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Binds alpha-importin and is mostly nuclear. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed with higher expression in heart, skeletal muscle and brain (at protein level). {ECO:0000269PubMed:12119119}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated |
Total |
13
[view]
|
Protein-Protein |
4
[view]
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Protein-DNA |
7
[view]
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Protein-RNA |
2
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
25 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006351
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transcription, DNA-templated
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GO:0007507
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heart development
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GO:0045736
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negative regulation of cyclin-dependent protein serine/threonine kinase activity
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GO:0045892
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negative regulation of transcription, DNA-templated
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Cellular Component |
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PDB ID |
MGI:2385923
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8R409
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PhosphoSite |
PhosphoSite-Q8R409
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TrEMBL |
Q8VDF7
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UniProt Splice Variant |
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Entrez Gene |
192231
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UniGene |
Mm.489620
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RefSeq |
NP_620092
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MGI ID |
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MGI Symbol |
Hexim1
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OMIM |
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CCDS |
CCDS25513
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HPRD |
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IMGT |
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EMBL |
AK134535
AL731805
AY090614
BC022111
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GenPept |
AAH22111
AAM09026
BAE22173
CAM22092
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