Mus musculus Protein: Hexim1
Summary
InnateDB Protein IDBP-212969.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hexim1
Protein Name hexamethylene bis-acetamide inducible 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000057339
InnateDB Gene IDBG-212967 (Hexim1)
Protein Structure
UniProt Annotation
Function Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Binds alpha-importin and is mostly nuclear. {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed with higher expression in heart, skeletal muscle and brain (at protein level). {ECO:0000269PubMed:12119119}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 4 [view]
Protein-DNA 7 [view]
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 protein binding
GO:0017069 snRNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0007507 heart development
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2385923
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R409
PhosphoSite PhosphoSite-Q8R409
TrEMBL Q8VDF7
UniProt Splice Variant
Entrez Gene 192231
UniGene Mm.489620
RefSeq NP_620092
MGI ID
MGI Symbol Hexim1
OMIM
CCDS CCDS25513
HPRD
IMGT
EMBL AK134535 AL731805 AY090614 BC022111
GenPept AAH22111 AAM09026 BAE22173 CAM22092