Version 5.4
Mus musculus Protein: Tpcn2
Summary
InnateDB Protein IDBP-212985.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tpcn2
Protein Name two pore segment channel 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000061308
InnateDB Gene IDBG-212981 (Tpcn2)
Protein Structure
UniProt Annotation
Function Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. Involved in smooth muscle contraction. {ECO:0000269PubMed:19387438, ECO:0000269PubMed:20495006, ECO:0000269PubMed:20547763}.
Subcellular Localization Lysosome membrane {ECO:0000269PubMed:19557428, ECO:0000269PubMed:20495006}; Multi- pass membrane protein {ECO:0000269PubMed:19557428, ECO:0000269PubMed:20495006}. Note=Only the acidic lysosomal fraction is sensitive to NAADP.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:19557428}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0042802 identical protein binding
GO:0072345 NAADP-sensitive calcium-release channel activity
Biological Process
GO:0006811 ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006939 smooth muscle contraction
GO:0034765 regulation of ion transmembrane transport
GO:0051209 release of sequestered calcium ion into cytosol
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2385297
InterPro IPR005821 Ion transport domain
PFAM PF00520
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BWC0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 233979
UniGene Mm.102235
RefSeq NP_666318
MGI ID
MGI Symbol Tpcn2
OMIM
CCDS CCDS40203
HPRD
IMGT
EMBL AK052930 AK090059 BC025890 BC069857
GenPept AAH25890 AAH69857 BAC35207 BAC41072

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca