Version 5.4
Mus musculus Protein: Plekhm1
Summary
InnateDB Protein IDBP-213031.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plekhm1
Protein Name pleckstrin homology domain containing, family M (with RUN domain) member 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000047327
InnateDB Gene IDBG-213029 (Plekhm1)
Protein Structure
UniProt Annotation
Function May have a role in sialyl-lex-mediated transduction of apoptotic signals. Involved in vesicular transport in the osteoclast (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0008150 biological_process
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2443207
InterPro IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR004012 RUN
IPR011011 Zinc finger, FYVE/PHD-type
PFAM PF00169
PF00130
PF02759
PRINTS
PIRSF
SMART SM00233
SM00109
SM00593
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7TSI1
PhosphoSite PhosphoSite-Q7TSI1
TrEMBL
UniProt Splice Variant
Entrez Gene 353047
UniGene Mm.383308
RefSeq NP_898855
MGI ID
MGI Symbol Plekhm1
OMIM
CCDS CCDS25518
HPRD
IMGT
EMBL AK154703 AL772325 AL929552 BC038943 BC053079
GenPept AAH38943 AAH53079 BAE32773 CAM16600 CAM17476

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca