InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wnt3

Summary

InnateDB Protein

IDBP-213060.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wnt3

Protein Name

wingless-related MMTV integration site 3

Synonyms

Int-4; Wnt-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000127

InnateDB Gene

IDBG-213058 (Wnt3)

Protein Structure

UniProt Annotation

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Note=Some mouse mammary tumors induced by mouse mammary tumor virus (MMTV) contain a provirus integrated into a host cell region which has been named Wnt3.

Tissue Specificity

Dorsal portion of the neural tube, dorsal ectoderm, the branchial arches, and the limb buds.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001707	mesoderm formation
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0007276	gamete generation
GO:0007411	axon guidance
GO:0009887	organ morphogenesis
GO:0009948	anterior/posterior axis specification
GO:0009950	dorsal/ventral axis specification
GO:0009952	anterior/posterior pattern specification
GO:0010628	positive regulation of gene expression
GO:0016055	Wnt signaling pathway
GO:0035115	embryonic forelimb morphogenesis
GO:0035116	embryonic hindlimb morphogenesis
GO:0044338	canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation
GO:0044339	canonical Wnt receptor signaling pathway involved in osteoblast differentiation
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048697	positive regulation of collateral sprouting in absence of injury
GO:0048843	negative regulation of axon extension involved in axon guidance
GO:0060064	Spemann organizer formation at the anterior end of the primitive streak
GO:0060070	canonical Wnt signaling pathway
GO:0060173	limb development
GO:0060174	limb bud formation
GO:0060323	head morphogenesis
GO:0061180	mammary gland epithelium development

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0031012	extracellular matrix