InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnf114

Summary

InnateDB Protein

IDBP-213065.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf114

Protein Name

ring finger protein 114

Synonyms

1110008J21Rik; AI225886; AW549494; Zfp228; Zfp313; Znf228;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077197

InnateDB Gene

IDBG-213061 (Rnf114)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0008150	biological_process
GO:0016567	protein ubiquitination
GO:0030154	cell differentiation

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1933159

InterPro

IPR001841 Zinc finger, RING-type
IPR008598 Drought induced 19 protein-like, zinc-binding domain
IPR015880 Zinc finger, C2H2-like
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF13639
PF14634
PF05605
PF00097

PRINTS

PIRSF

SMART

SM00184
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ET26