InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PXDNL

Summary

InnateDB Protein

IDBP-21308.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PXDNL

Protein Name

peroxidasin homolog (Drosophila)-like

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000348645

InnateDB Gene

IDBG-21306 (PXDNL)

Protein Structure

UniProt Annotation

Function

Isoform PMR1: Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs. {ECO:0000269PubMed:22543864}.

Subcellular Localization

Secreted {ECO:0000305}.Isoform PMR1: Cytoplasm. Note=Associates with polysomes.

Disease Associations

Tissue Specificity

the 57 kDa isoform PMR1 is the only form detected at protein levels in human cell lines. {ECO:0000269PubMed:22543864}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004519	endonuclease activity
GO:0004601	peroxidase activity
GO:0005515	protein binding
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0006979	response to oxidative stress
GO:0042744	hydrogen peroxide catabolic process
GO:0055114	oxidation-reduction process
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000483 Cysteine-rich flanking region, C-terminal
IPR001007 von Willebrand factor, type C
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR010255 Haem peroxidase
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR019791 Haem peroxidase, animal

PFAM