Version 5.4
| Mus musculus Protein: Mrc2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-213232.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Mrc2 | ||||||||
| Protein Name | mannose receptor, C type 2 | ||||||||
| Synonyms | Endo180; mKIAA0709; uPARAP; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000097909 | ||||||||
| InnateDB Gene | IDBG-213230 (Mrc2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). {ECO:0000269PubMed:12668656, ECO:0000269PubMed:14729061, ECO:0000269PubMed:15967816}. | ||||||||
| Subcellular Localization | Membrane; Single-pass type I membrane protein. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Highly expressed in heart, lung and kidney, but little or no expression in brain, thymus or adult liver. Expressed at highly endothelialized sites such as those in choroid plexus and kidney glomerulai as well as in chondrocytes in cartilaginous regions of the embryo. {ECO:0000269PubMed:8702911}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:107818 | ||||||||
| InterPro |
IPR000562
Fibronectin, type II, collagen-binding IPR000772 Ricin B lectin domain IPR001304 C-type lectin IPR002353 Type-2 ice-structuring protein IPR013806 Kringle-like fold IPR016187 C-type lectin fold |
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| PFAM |
PF00040
PF00652 PF14200 PF00059 |
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| PRINTS |
PR00356
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| PIRSF | |||||||||
| SMART |
SM00059
SM00458 SM00034 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q64449 | ||||||||
| PhosphoSite | PhosphoSite-Q64449 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 17534 | ||||||||
| UniGene | Mm.235616 | ||||||||
| RefSeq | NP_032652 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Mrc2 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS25539 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK054150 AK129195 AL645471 AL645572 AL645684 U56734 | ||||||||
| GenPept | AAC52729 BAC35672 BAC98005 CAM22193 CAM22804 CAM24832 | ||||||||