Version 5.4
Mus musculus Protein: Cass4
Summary
InnateDB Protein IDBP-213300.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cass4
Protein Name Cas scaffolding protein family member 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000096660
InnateDB Gene IDBG-213298 (Cass4)
Protein Structure
UniProt Annotation
Function Docking protein that plays a role in tyrosine kinase- based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250UniProtKB:Q9NQ75}. Cell junction, focal adhesion {ECO:0000250UniProtKB:Q9NQ75}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
Protein Structure and Domains
PDB ID MGI:2444482
InterPro IPR001452 SH3 domain
IPR011511 Variant SH3 domain
IPR014928 Serine rich protein interaction
PFAM PF00018
PF14604
PF07653
PF08824
PRINTS PR00452
PIRSF
SMART SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q08EC4
PhosphoSite PhosphoSite-Q08EC4
TrEMBL
UniProt Splice Variant
Entrez Gene 320664
UniGene Mm.210195
RefSeq NP_001028710
MGI ID
MGI Symbol Cass4
OMIM
CCDS
HPRD
IMGT
EMBL AK170726 AL833787 BC117858 BC117859 BC129975 BC129976
GenPept AAI17859 AAI17860 AAI29976 AAI29977 BAE41983 CAM18024 CAM18025

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca