InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tfap2c

Summary

InnateDB Protein

IDBP-213322.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tfap2c

Protein Name

transcription factor AP-2, gamma

Synonyms

AA409384; Ap-2.2; AP2gamma; Stra2; Tcfap2c;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030391

InnateDB Gene

IDBG-213320 (Tfap2c)

Protein Structure

UniProt Annotation

Function

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in lung, ovary and testis. Expressed in most squamous epithelia. Also, detected in several exocrine glands including the prostate, the preputial and salivary glands, serous glands of the tongue and ocular harderian glands.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001829	trophectodermal cell differentiation
GO:0001942	hair follicle development
GO:0003334	keratinocyte development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008584	male gonad development
GO:0019827	stem cell maintenance
GO:0021877	forebrain neuron fate commitment
GO:0021987	cerebral cortex development
GO:0030154	cell differentiation
GO:0030718	germ-line stem cell maintenance
GO:0035019	somatic stem cell maintenance
GO:0043588	skin development
GO:0045682	regulation of epidermis development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048733	sebaceous gland development
GO:0060598	dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation