InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tfap2c

Summary

InnateDB Protein

IDBP-213324.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Tfap2c

Protein Name

transcription factor AP-2, gamma

Synonyms

AA409384; Ap-2.2; AP2gamma; Stra2; Tcfap2c;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000096657

InnateDB Gene

IDBG-213320 (Tfap2c)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001829	trophectodermal cell differentiation
GO:0001942	hair follicle development
GO:0003334	keratinocyte development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008584	male gonad development
GO:0019827	stem cell maintenance
GO:0021877	forebrain neuron fate commitment
GO:0021987	cerebral cortex development
GO:0030154	cell differentiation
GO:0030718	germ-line stem cell maintenance
GO:0035019	somatic stem cell maintenance
GO:0043588	skin development
GO:0045682	regulation of epidermis development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048733	sebaceous gland development
GO:0060598	dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:106032

InterPro

IPR008123 Transcription factor AP-2 gamma
IPR013854 Transcription factor AP-2, C-terminal

PFAM

PF03299

PRINTS

PR01751
PR01748

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q3ULB3

UniProt Splice Variant

Entrez Gene

21420

UniGene

Mm.413057

RefSeq

MGI ID

MGI Symbol

Tfap2c

OMIM

CCDS

HPRD

IMGT

EMBL

AK145603 AL833787

GenPept

BAE26536