InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bmp7

Summary

InnateDB Protein

IDBP-213332.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bmp7

Protein Name

bone morphogenetic protein 7

Synonyms

OP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000009143

InnateDB Gene

IDBG-213330 (Bmp7)

Protein Structure

UniProt Annotation

Function

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding
GO:0070700	BMP receptor binding

Biological Process

GO:0001503	ossification
GO:0001654	eye development
GO:0001656	metanephros development
GO:0001657	ureteric bud development
GO:0001707	mesoderm formation
GO:0001822	kidney development
GO:0001823	mesonephros development
GO:0007389	pattern specification process
GO:0007411	axon guidance
GO:0007435	salivary gland morphogenesis
GO:0008285	negative regulation of cell proliferation
GO:0009880	embryonic pattern specification
GO:0009887	organ morphogenesis
GO:0010800	positive regulation of peptidyl-threonine phosphorylation
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010942	positive regulation of cell death
GO:0030326	embryonic limb morphogenesis
GO:0030501	positive regulation of bone mineralization
GO:0030509	BMP signaling pathway
GO:0030855	epithelial cell differentiation
GO:0032355	response to estradiol
GO:0033280	response to vitamin D
GO:0034116	positive regulation of heterotypic cell-cell adhesion
GO:0034504	protein localization to nucleus
GO:0035239	tube morphogenesis
GO:0040007	growth
GO:0042325	regulation of phosphorylation
GO:0042326	negative regulation of phosphorylation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043065	positive regulation of apoptotic process
GO:0043401	steroid hormone mediated signaling pathway
GO:0043407	negative regulation of MAP kinase activity
GO:0043434	response to peptide hormone
GO:0045597	positive regulation of cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045746	negative regulation of Notch signaling pathway
GO:0045786	negative regulation of cell cycle
GO:0045839	negative regulation of mitosis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048468	cell development
GO:0048593	camera-type eye morphogenesis
GO:0048596	embryonic camera-type eye morphogenesis
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048754	branching morphogenesis of an epithelial tube
GO:0048762	mesenchymal cell differentiation
GO:0048812	neuron projection morphogenesis
GO:0050768	negative regulation of neurogenesis
GO:0051216	cartilage development
GO:0060272	embryonic skeletal joint morphogenesis
GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395	SMAD protein signal transduction
GO:0060445	branching involved in salivary gland morphogenesis
GO:0060485	mesenchyme development
GO:0060548	negative regulation of cell death
GO:0060686	negative regulation of prostatic bud formation
GO:0060687	regulation of branching involved in prostate gland morphogenesis
GO:0070487	monocyte aggregation
GO:0072040	negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
GO:0072125	negative regulation of glomerular mesangial cell proliferation
GO:0072133	metanephric mesenchyme morphogenesis
GO:0072134	nephrogenic mesenchyme morphogenesis
GO:0072136	metanephric mesenchymal cell proliferation involved in metanephros development
GO:1900006	positive regulation of dendrite development
GO:1900106	positive regulation of hyaluranon cable assembly