InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Strada

Summary

InnateDB Protein

IDBP-213389.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Strada

Protein Name

STE20-related kinase adaptor alpha

Synonyms

2610019A05Rik; 6030402H20Rik; AI480680; E130112C09Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099361

InnateDB Gene

IDBG-213381 (Strada)

Protein Structure

UniProt Annotation

Function

Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250UniProtKB:Q7RTN6}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019900	kinase binding
GO:0030295	protein kinase activator activity

Biological Process

GO:0006468	protein phosphorylation
GO:0006611	protein export from nucleus
GO:0007049	cell cycle
GO:0032147	activation of protein kinase activity
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1919399

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt