InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALKBH7

Summary

InnateDB Protein

IDBP-21344.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALKBH7

Protein Name

alkB, alkylation repair homolog 7 (E. coli)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000245812

InnateDB Gene

IDBG-21342 (ALKBH7)

Protein Structure

UniProt Annotation

Function

Probable dioxygenase required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism. {ECO:0000269PubMed:23666923}.

Subcellular Localization

Mitochondrion matrix {ECO:0000269PubMed:23666923}.

Disease Associations

Tissue Specificity

Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta. {ECO:0000269PubMed:17979886}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity

Biological Process

GO:0006631	fatty acid metabolic process
GO:0006974	cellular response to DNA damage stimulus
GO:0010883	regulation of lipid storage
GO:0055114	oxidation-reduction process
GO:1902445	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death