InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gnas

Summary

InnateDB Protein

IDBP-213446.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gnas

Protein Name

GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus

Synonyms

5530400H20Rik; A930027G11Rik; C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gsa; GSP; Nesp; Nespl; Oed-Sml; Oedsml; P1; P2; P3; PHP1A; PHP1B; POH;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000085179

InnateDB Gene

IDBG-213434 (Gnas)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Stimulates the Ras signaling pathway via RAPGEF2.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:8227063}; Lipid-anchor {ECO:0000269PubMed:8227063}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0031852	mu-type opioid receptor binding
GO:0035255	ionotropic glutamate receptor binding
GO:0046872	metal ion binding

Biological Process

GO:0001501	skeletal system development
GO:0001894	tissue homeostasis
GO:0001958	endochondral ossification
GO:0006112	energy reserve metabolic process
GO:0006184	GTP catabolic process
GO:0006306	DNA methylation
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007606	sensory perception of chemical stimulus
GO:0009791	post-embryonic development
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0032320	positive regulation of Ras GTPase activity
GO:0035116	embryonic hindlimb morphogenesis
GO:0035264	multicellular organism growth
GO:0040032	post-embryonic body morphogenesis
GO:0042493	response to drug
GO:0043588	skin development
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0045669	positive regulation of osteoblast differentiation
GO:0045672	positive regulation of osteoclast differentiation
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0051216	cartilage development
GO:0071514	genetic imprinting
GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway

Cellular Component

GO:0005834	heterotrimeric G-protein complex
GO:0016020	membrane
GO:0030425	dendrite
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane

Protein Structure and Domains

PDB ID

MGI:95777

InterPro

IPR000367 G-protein alpha subunit, group S
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR011025 G protein alpha subunit, helical insertion
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00503
PF00025

PRINTS

PR00443
PR00318
PR00328

PIRSF

SMART

SM00275

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt