InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scn4a

Summary

InnateDB Protein

IDBP-213460.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scn4a

Protein Name

sodium channel, voltage-gated, type IV, alpha

Synonyms

mH2; Nav1.4; SkM1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021056

InnateDB Gene

IDBG-213458 (Scn4a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0019228	neuronal action potential
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:98250

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001696 Voltage gated sodium channel, alpha subunit
IPR003915 Polycystic kidney disease type 2 protein
IPR005821 Ion transport domain
IPR008052 Voltage gated sodium channel, alpha-4 subunit, mammalian
IPR010526 Sodium ion transport-associated
IPR013122 Polycystin cation channel, PKD1/PKD2

PFAM

PF00612
PF00520
PF06512
PF08016

PRINTS

PR00170
PR01433
PR01665

PIRSF

SMART

SM00015

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt