InnateDB Protein
|
IDBP-213487.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Atp5e
|
Protein Name
|
ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
|
Synonyms
|
2410043G19Rik; ATPE; AV000645;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000016396
|
InnateDB Gene
|
IDBG-213485 (Atp5e)
|
Protein Structure
|
|
Function |
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Mitochondrion. Mitochondrion inner membrane.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
2 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0008553
|
hydrogen-exporting ATPase activity, phosphorylative mechanism
|
GO:0046933
|
proton-transporting ATP synthase activity, rotational mechanism
|
GO:0046961
|
proton-transporting ATPase activity, rotational mechanism
|
|
Biological Process |
|
Cellular Component |
GO:0000275
|
mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
|
GO:0005739
|
mitochondrion
|
GO:0005743
|
mitochondrial inner membrane
|
GO:0005753
|
mitochondrial proton-transporting ATP synthase complex
|
|
PDB ID |
MGI:1855697
|
InterPro |
IPR006721
ATPase, F1 complex, epsilon subunit, mitochondrial
|
PFAM |
PF04627
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P56382
|
PhosphoSite |
PhosphoSite-P56382
|
TrEMBL |
Q545F5
|
UniProt Splice Variant |
|
Entrez Gene |
67126
|
UniGene |
Mm.20841
|
RefSeq |
NP_080259
|
MGI ID |
|
MGI Symbol |
Atp5e
|
OMIM |
|
CCDS |
CCDS38360
|
HPRD |
|
IMGT |
|
EMBL |
AK007809
AK010661
AK012444
AK131585
AK160387
BC024339
CH466551
|
GenPept |
AAH24339
BAB25274
BAB27098
BAB28243
BAE20702
BAE35759
EDL06680
EDL06681
|
|
|