InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pecam1

Summary

InnateDB Protein

IDBP-213509.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pecam1

Protein Name

platelet/endothelial cell adhesion molecule 1

Synonyms

C85791; Cd31; Pecam; PECAM-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079664

InnateDB Gene

IDBG-213505 (Pecam1)

Protein Structure

UniProt Annotation

Function

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Modulates BDKRB2 activation (By similarity). Induces susceptibility to atherosclerosis. {ECO:0000250, ECO:0000269PubMed:19048083}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 3 are expressed in lung and platelets. {ECO:0000269PubMed:18388311}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0002687	positive regulation of leukocyte migration
GO:0006928	cellular component movement
GO:0007155	cell adhesion
GO:0007266	Rho protein signal transduction
GO:0030334	regulation of cell migration
GO:0030837	negative regulation of actin filament polymerization
GO:0034097	response to cytokine
GO:0034259	negative regulation of Rho GTPase activity
GO:0042060	wound healing
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation

Cellular Component

GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030485	smooth muscle contractile fiber
GO:0045121	membrane raft
GO:0071944	cell periphery