InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RFTN1

Summary

InnateDB Protein

IDBP-21353.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RFTN1

Protein Name

raftlin, lipid raft linker 1

Synonyms

PIB10; PIG9; RAFTLIN;

Species

Homo sapiens

Ensembl Protein

ENSP00000334153

InnateDB Gene

IDBG-21351 (RFTN1)

Protein Structure

UniProt Annotation

Function

May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen receptor- mediated signaling. {ECO:0000269PubMed:12805216}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12805216}; Lipid-anchor {ECO:0000269PubMed:12805216}. Note=Associates with lipid rafts.

Disease Associations

Tissue Specificity

Specifically expressed by B-cells (at protein level). {ECO:0000269PubMed:12805216}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding

Biological Process

GO:0001765	membrane raft assembly
GO:0002457	T cell antigen processing and presentation
GO:0032596	protein transport into membrane raft
GO:0032620	interleukin-17 production
GO:0033227	dsRNA transport
GO:0034138	toll-like receptor 3 signaling pathway
GO:0040007	growth
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response (InnateDB)
GO:0050852	T cell receptor signaling pathway
GO:0050853	B cell receptor signaling pathway
GO:1903044	protein localization to membrane raft

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome