InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sycp2

Summary

InnateDB Protein

IDBP-213679.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sycp2

Protein Name

synaptonemal complex protein 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079909

InnateDB Gene

IDBG-213677 (Sycp2)

Protein Structure

UniProt Annotation

Function

Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements. {ECO:0000269PubMed:11463847, ECO:0000269PubMed:16717126}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome {ECO:0000269PubMed:22346761}. Note=In axial/lateral elements of the tripartite segments of synaptonemal complexes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0007140	male meiosis
GO:0007143	female meiotic division
GO:0009566	fertilization
GO:0009887	organ morphogenesis
GO:0043066	negative regulation of apoptotic process
GO:0048808	male genitalia morphogenesis