InnateDB Protein
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IDBP-21372.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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USPL1
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Protein Name
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ubiquitin specific peptidase like 1
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Synonyms
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bA121O19.1; C13orf22; D13S106E;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000255304
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InnateDB Gene
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IDBG-21370 (USPL1)
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Protein Structure
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Function |
SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms. May have non-catalytic functions in Cajal bodies organization and cell proliferation. {ECO:0000269PubMed:22878415}.
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Subcellular Localization |
Nucleus, Cajal body {ECO:0000269PubMed:22878415}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
26
[view]
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Protein-Protein |
24
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR028889
Ubiquitin carboxyl-terminal hydrolase-like domain
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5W0Q7
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PhosphoSite |
PhosphoSite-Q5W0Q7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10208
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UniGene |
Hs.598587
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RefSeq |
NP_005791
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HUGO |
HGNC:20294
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OMIM |
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CCDS |
CCDS9336
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HPRD |
09833
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IMGT |
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EMBL |
AL138681
BC036027
BC038103
CR627370
X59131
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GenPept |
AAH36027
AAH38103
CAA41848
CAH10469
CAH70264
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