InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psma7

Summary

InnateDB Protein

IDBP-213732.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psma7

Protein Name

proteasome (prosome, macropain) subunit, alpha type 7

Synonyms

C6-I;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029082

InnateDB Gene

IDBG-213730 (Psma7)

Protein Structure

UniProt Annotation

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions (By similarity). The interaction with EMAP2 increases the proteasome-mediated HIF- 1A degradation under the hypoxic conditions (By similarity). Promotes MAVS degradation and thereby negatively regulates MAVS- mediated innate immune response (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Detected in liver (at protein level). {ECO:0000269PubMed:22341445}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 97 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	97 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004298	threonine-type endopeptidase activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0051603	proteolysis involved in cellular protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0005839	proteasome core complex
GO:0019773	proteasome core complex, alpha-subunit complex
GO:0070062	extracellular vesicular exosome