Version 5.4
Mus musculus Protein: Cacng5
Summary
InnateDB Protein IDBP-213735.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cacng5
Protein Name calcium channel, voltage-dependent, gamma subunit 5
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000047888
InnateDB Gene IDBG-213733 (Cacng5)
Protein Structure
UniProt Annotation
Function Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}.
Disease Associations
Tissue Specificity Brain. Enriched in Bergman glia, as well as a variety of neuronal populations including locus coeruleus, olfactory bulb, lateral septal nucleus, interpeduncular nucleus,and the CA2 and rostral/medial CA1 regions of hippocampus. {ECO:0000269PubMed:18817736}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005244 voltage-gated ion channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0070588 calcium ion transmembrane transport
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Cellular Component
GO:0014069 postsynaptic density
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID MGI:2157946
InterPro IPR004031 PMP-22/EMP/MP20/Claudin superfamily
IPR008368 Voltage-dependent calcium channel, gamma subunit
IPR008369 Voltage-dependent calcium channel, gamma-5 subunit
PFAM PF00822
PF13903
PRINTS PR01792
PR01793
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VHW4
PhosphoSite PhosphoSite-Q8VHW4
TrEMBL Q544Q4
UniProt Splice Variant
Entrez Gene 140723
UniGene Mm.87663
RefSeq NP_001186230
MGI ID
MGI Symbol Cacng5
OMIM
CCDS CCDS25572
HPRD
IMGT
EMBL AF361347 AK032260 AK032548 AK034065 AK080762 BC120894 BC120895 CH466558
GenPept AAI20895 AAI20896 AAL50042 BAC27783 BAC27920 BAC28568 BAC38012 EDL34337 EDL34338

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca