InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lama5

Summary

InnateDB Protein

IDBP-213781.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lama5

Protein Name

laminin, alpha 5

Synonyms

[a]5; AA408760; AA408762; AI853660; laminin-511; mKIAA0533;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015791

InnateDB Gene

IDBG-213777 (Lama5)

Protein Structure

UniProt Annotation

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Alpha-5 may be the major laminin alpha chain of adult epithelial and/or endothelial basal laminae.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Disease Associations

Tissue Specificity

In adult, high levels in heart, lung, and kidney; lower in brain, muscle and testis; very low in liver, gut and skin. Expressed in many tissues in embryonic day 11.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005178	integrin binding
GO:0005515	protein binding

Biological Process

GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001738	morphogenesis of a polarized epithelium
GO:0001755	neural crest cell migration
GO:0001942	hair follicle development
GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007517	muscle organ development
GO:0009887	organ morphogenesis
GO:0016331	morphogenesis of embryonic epithelium
GO:0016477	cell migration
GO:0030155	regulation of cell adhesion
GO:0030324	lung development
GO:0030334	regulation of cell migration
GO:0034446	substrate adhesion-dependent cell spreading
GO:0042127	regulation of cell proliferation
GO:0042384	cilium assembly
GO:0042475	odontogenesis of dentin-containing tooth
GO:0045995	regulation of embryonic development
GO:0048754	branching morphogenesis of an epithelial tube
GO:0060445	branching involved in salivary gland morphogenesis
GO:0090002	establishment of protein localization to plasma membrane

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005605	basal lamina
GO:0005606	laminin-1 complex
GO:0005610	laminin-5 complex
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0031012	extracellular matrix
GO:0043259	laminin-10 complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:105382

InterPro

IPR000034 Laminin B type IV
IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR002049 EGF-like, laminin
IPR008211 Laminin, N-terminal
IPR008979 Galactose-binding domain-like
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR009053 Prefoldin
IPR009254 Laminin I
IPR010307 Laminin II
IPR018031 Laminin B, subgroup

PFAM