InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eef1a2

Summary

InnateDB Protein

IDBP-214012.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eef1a2

Protein Name

eukaryotic translation elongation factor 1 alpha 2

Synonyms

Eef1a; S1; wasted; wst;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000054556

InnateDB Gene

IDBG-214010 (Eef1a2)

Protein Structure

UniProt Annotation

Function

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Found in a wide range of tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003746	translation elongation factor activity
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006414	translational elongation
GO:0010035	response to inorganic substance
GO:0043065	positive regulation of apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005853	eukaryotic translation elongation factor 1 complex
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:1096317

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR004160 Translation elongation factor EFTu/EF1A, C-terminal
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR004539 Translation elongation factor EF1A, eukaryotic/archaeal
IPR009000 Translation protein, beta-barrel domain
IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF03143
PF03144

PRINTS

PR00315

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P62631