InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rtel1

Summary

InnateDB Protein

IDBP-214072.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rtel1

Protein Name

regulator of telomere elongation helicase 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053120

InnateDB Gene

IDBG-214068 (Rtel1)

Protein Structure

UniProt Annotation

Function

ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. {ECO:0000255HAMAP- Rule:MF_03065, ECO:0000269PubMed:15210109, ECO:0000269PubMed:22579284, ECO:0000269PubMed:22593209, ECO:0000269PubMed:24115439}.

Subcellular Localization

Nucleus {ECO:0000255HAMAP-Rule:MF_03065, ECO:0000269PubMed:15210109, ECO:0000269PubMed:24115439}. Note=Colocalizes with PCNA within the replication foci in S-phase cells.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in spleen, thymus, Peyer patches, kidney, and intestine. Not expressed in brain, heart, lung, skeletal muscles, skin and white fat. In the adult gonad, it is highly expressed in the testis, mainly in the spermatogonia and meiotic spermatocytes. {ECO:0000269PubMed:15210109}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0000723	telomere maintenance
GO:0006139	nucleobase-containing compound metabolic process
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0010569	regulation of double-strand break repair via homologous recombination
GO:0032508	DNA duplex unwinding

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:2139369

InterPro

IPR006554 Helicase-like, DEXD box c2 type
IPR006555 ATP-dependent helicase, C-terminal
IPR010614 DEAD2
IPR013020 DNA helicase (DNA repair), Rad3 type
IPR014013 Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF13307
PF06733

PRINTS

PIRSF

SMART

SM00488
SM00491

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0VGM9