InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnajc5

Summary

InnateDB Protein

IDBP-214136.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnajc5

Protein Name

DnaJ (Hsp40) homolog, subfamily C, member 5

Synonyms

2610314I24Rik; AU018536; Csp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072175

InnateDB Gene

IDBG-214134 (Dnajc5)

Protein Structure

UniProt Annotation

Function

May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000269PubMed:17034881}; Lipid-anchor {ECO:0000269PubMed:17034881}. Melanosome {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with insulin granules, when overexpressed in a islet cell line.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0043008	ATP-dependent protein binding

Biological Process

GO:0043524

negative regulation of neuron apoptotic process

Cellular Component

GO:0005739	mitochondrion
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome