Version 5.4
Mus musculus Protein: Cd300lh
Summary
InnateDB Protein IDBP-214203.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd300lh
Protein Name CD300 antigen like family member H
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000090116
InnateDB Gene IDBG-214201 (Cd300lh)
Protein Structure
UniProt Annotation
Function Acts as an activating receptor inducing cytokine production in mast cells. Can act as a positive regulator of TLR9 signaling in macrophages, leading to enhanced production of proinflammatory cytokines. {ECO:0000269PubMed:20817736, ECO:0000269PubMed:21940676}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Early endosome {ECO:0000269PubMed:21940676}. Lysosome {ECO:0000269PubMed:21940676}.
Disease Associations
Tissue Specificity Highly expressed in bone marrow-derived mast cells and macrophages, peripheral blood monocytes and CD11c+ cells, with weaker expression detected in CD11b cells in bone marrow and peripheral blood. Not detected in B220+ cells in bone marrow or spleen, in Thy-1.2+ or CD3+ cells in peripheral blood, spleen or thymus, or in NK1.1+ cells in spleen (at protein level). Widely expressed in various tissues including heart, liver, spleen, lung, kidney, brain, bone marrow, thymus, axillary lymph node and mesenteric lymph node. Highly expressed in macrophage cell lines J774.1 and RAW 264.7 and in mast cell line MC/9. Weak expression detected in B-lineage cell lines WEHI-231 and A20 and in dendritic cell line DC2.4. Not detected in other myeloid cell lines or T-lineage cell lines. {ECO:0000269PubMed:20817736, ECO:0000269PubMed:21940676}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002376 immune system process
GO:0031398 positive regulation of protein ubiquitination
GO:0034165 positive regulation of toll-like receptor 9 signaling pathway
Cellular Component
GO:0005764 lysosome
GO:0005768 endosome
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2687214
InterPro IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6SJQ5
PhosphoSite PhosphoSite-Q6SJQ5
TrEMBL
UniProt Splice Variant
Entrez Gene 382551
UniGene
RefSeq NP_954671
MGI ID
MGI Symbol Cd300lh
OMIM
CCDS CCDS25617
HPRD
IMGT
EMBL AL607025 AY457049 BC119352 BC120623
GenPept AAI19353 AAI20624 AAR27940 CAM21179

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca