Version 5.4
Mus musculus Protein: Fdxr
Summary
InnateDB Protein IDBP-214270.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fdxr
Protein Name ferredoxin reductase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000021078
InnateDB Gene IDBG-214268 (Fdxr)
Protein Structure
UniProt Annotation
Function Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
Subcellular Localization Mitochondrion matrix.
Disease Associations
Tissue Specificity Expressed in the adrenal, testis and ovary and to a lesser extent in the liver and kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015039 NADPH-adrenodoxin reductase activity
GO:0016491 oxidoreductase activity
GO:0070402 NADPH binding
Biological Process
GO:0008203 cholesterol metabolic process
GO:0055114 oxidation-reduction process
GO:0070995 NADPH oxidation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID MGI:104724
InterPro IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain
PFAM PF07992
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61578
PhosphoSite PhosphoSite-Q61578
TrEMBL Q3UZ58
UniProt Splice Variant
Entrez Gene 14149
UniGene Mm.4719
RefSeq NP_032023
MGI ID
MGI Symbol Fdxr
OMIM
CCDS CCDS25625
HPRD
IMGT
EMBL AK134068 D49920
GenPept BAA08659 BAE22000

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca