InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nup85

Summary

InnateDB Protein

IDBP-214326.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nup85

Protein Name

nucleoporin 85

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021085

InnateDB Gene

IDBG-214324 (Nup85)

Protein Structure

UniProt Annotation

Function

Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP98/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2- activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl- inositol 3-kinase-Rac-lammellipodium protrusion cascade.

Subcellular Localization

Nucleus, nuclear pore complex {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus membrane {ECO:0000250}. Note=During mitosis, localizes to the kinetochores and spindle poles. Upon CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of migrating cells (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031727	CCR2 chemokine receptor binding

Biological Process

GO:0006935	chemotaxis
GO:0015031	protein transport
GO:0019221	cytokine-mediated signaling pathway
GO:0030032	lamellipodium assembly
GO:0048246	macrophage chemotaxis
GO:0051028	mRNA transport

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000922	spindle pole
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031080	nuclear pore outer ring
GO:0031965	nuclear membrane