Version 5.4
Mus musculus Protein: H3f3b
Summary
InnateDB Protein IDBP-214395.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol H3f3b
Protein Name H3 histone, family 3B
Synonyms 9430068D06Rik; H3.3A; H3.3B;
Species Mus musculus
Ensembl Protein ENSMUSP00000016703
InnateDB Gene IDBG-214393 (H3f3b)
Protein Structure
UniProt Annotation
Function Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization Nucleus. Chromosome.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
GO:0007420 brain development
GO:0009725 response to hormone
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
Protein Structure and Domains
PDB ID MGI:1101768
InterPro IPR000164 Histone H3
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00125
PRINTS PR00622
PIRSF
SMART SM00428
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P84244
PhosphoSite PhosphoSite-P84244
TrEMBL E0CZ27
UniProt Splice Variant
Entrez Gene 667250
UniGene Mm.457659
RefSeq NP_032237
MGI ID
MGI Symbol H3f3b
OMIM
CCDS CCDS36377
HPRD
IMGT
EMBL AC121292 AK002928 AK011431 AK037900 AK088075 AK135839 AK150467 AK150468 AK150591 AK150928 AK151274 AK151336 AK151451 AK151634 AK151658 AK151661 AK151869 AK152293 AK152453 AK152455 AK152623 AK152911 AK153034 AK153189 AK153239 AK153294 AK153371 AK153530 AK159615 AK159807 AK159850 AK160677 AK161675 AK162040 AK163244 AK167828 AK167879 AK168197 AK168698 AK169042 AK169226 AY383567 BC002268 BC012687 BC021768 BC037730 BC083353 BC088835 BC092043 BC092300 BC106177 X13605 X91866 Z85979
GenPept AAH02268 AAH12687 AAH21768 AAH37730 AAH83353 AAH88835 AAH92043 AAH92300 AAI06178 AAQ96274 BAB22464 BAB27616 BAC29895 BAC40130 BAE22687 BAE29584 BAE29585 BAE29685 BAE29966 BAE30261 BAE30314 BAE30411 BAE30566 BAE30586 BAE30589 BAE30757 BAE31102 BAE31231 BAE31233 BAE31366 BAE31590 BAE31666 BAE31789 BAE31831 BAE31877 BAE31939 BAE32069 BAE35232 BAE35387 BAE35427 BAE35953 BAE36524 BAE36694 BAE37253 BAE39850 BAE39892 BAE40157 BAE40542 BAE40831 BAE40995 CAA31940 CAB06625

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca