Version 5.4
Mus musculus Protein: Ten1
Summary
InnateDB Protein IDBP-214428.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ten1
Protein Name RIKEN cDNA 2310004N24 gene
Synonyms 2310004N24Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000021130
InnateDB Gene IDBG-214426 (Ten1)
Protein Structure
UniProt Annotation
Function Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. {ECO:0000269PubMed:19854130}.
Subcellular Localization Nucleus {ECO:0000269PubMed:19854130}. Chromosome, telomere {ECO:0000269PubMed:19854130}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0000784 nuclear chromosome, telomeric region
GO:0005634 nucleus
GO:0070188 Stn1-Ten1 complex
Protein Structure and Domains
PDB ID MGI:1916785
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D7K2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 69535
UniGene Mm.390347
RefSeq NP_081383
MGI ID
MGI Symbol Ten1
OMIM
CCDS CCDS48982
HPRD
IMGT
EMBL AK009156 AK146257 AL669925 BC027639
GenPept AAH27639 BAB26112 BAE27018 CAM16382

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca